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Current Video: NFL on FOX: SF-IND Preview

Peyton Manning and the undefeated Colts host the 49ers. NFL on FOX analyst Tim Ryan has a preview of the matchup.

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Full Transcript (Automatically generated. May not be 100% accurate)

" Everybody to Bryant with fox sports well as you can see we're in the storage closet. This week in Indianapolis because the forty niner fans here crazier and votes so it comes their football team. San Francisco organizes the Indianapolis Colts is really should be good matchup on paper a lot of people may not think so. But I believe it's going to be I know San Francisco very very good about the defensive plan. At least -- Peyton Manning can do with the passing game or statements seriously get Greg and ask you a great line. The coronet San Francisco it's hard to stop Peyton Manning -- best offensive coordinator in the league and he actually played so. San Francisco's starting fast on defense like so they let their plan as an absolute teach. So they can keep it close and don't wanna do offensively Jimmy -- the office coordinator talked Alex mythical quarterback whose ox gets star Alex. Talked about on the football they've got to have balance in this football game no we did he a lot of this Brett. Principles in that second half against Houston Texans last week Crabtree makes a big difference. Course out there and you talk. They can achieve that they want to but I would expect balance trying to run the football and and I would think Alex Smith against that defense which really hasn't been tested for Indianapolis now. But very very good when they have to be. Alex Smith likes his match -- in particular Vernon Davis though the middle everybody check out the game. I think it's going to be here at one big big test for San Francisco 49ers Indianapolis has not lost here at home. Since early in the season. Last year -- subject's. Words checking out."

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